Berberine (HCl) — intervention evidence review — Supplement & Protocol Data

**HbA1c and plasma glucose in type 2 diabetes** (HbA1c, FPG, 2-h postprandial glucose).
**Lipids** (LDL-C, total cholesterol, triglycerides, HDL-C) in dyslipidemia or T2D.
**PCOS** (HOMA-IR, androgens / SHBG, waist, ovulation / IVF live birth).
**NAFLD** (hepatic fat by 1H-MRS or ultrasound; ALT / AST / GGT).
**Weight / BMI / waist** as a metabolic side-effect or a primary obesity claim.
**“As good as metformin”** — treated here as its own claim, not as proof of the glucose claim.
**Better GI tolerance than metformin** — a tolerability claim, not a benefit.

Berberine (HCl) — intervention evidence review