What it is
Regulatory status: sold in dietary supplements and in prescription-strength medical foods or products depending dose and market
Mechanism evidence: human
At a glance
What it is, why people use it, the evidence, and what to know before trying it.
Why people use it
- Correct folate deficiency
- Support homocysteine metabolism
Evidence at a glance
L-methylfolate is a biologically active folate source, but a methylated form is not a universal upgrade. Use should be driven by diet, laboratory context, diagnosis and dose rather than an MTHFR result alone.
Confidence: moderate
Safety & interactions
Known side effects, interactions and use limits from reviewed sources.
High folate intake can mask hematologic signs of vitamin B12 deficiency while neurologic injury progresses. Dose, B12 status, medicines and the reason for use should be reviewed.
Forms and variants
This review does not automatically apply to:
- folic acid
- folinic acid
- unresolved B-complex products
Found in blends & products
L-methylfolate is listed as an ingredient or component in these reviewed interventions.