Safety & interactions
High folate intake can mask hematologic signs of vitamin B12 deficiency while neurologic injury progresses. Dose, B12 status, medicines and the reason for use should be reviewed.
L-methylfolate supplies the circulating folate form used in one-carbon metabolism and homocysteine remethylation. Correcting folate deficiency is established; benefits in replete people or based solely on common MTHFR variants are not automatic.
Purpose, evidence and practical considerations.
High folate intake can mask hematologic signs of vitamin B12 deficiency while neurologic injury progresses. Dose, B12 status, medicines and the reason for use should be reviewed.
Regulatory status: sold in dietary supplements and in prescription-strength medical foods or products depending dose and market
The evidence on this page does not automatically apply to:
L-methylfolate is listed as an ingredient or component in these reviewed interventions.