Safety & interactions
Vitamin C has low toxicity, but high oral doses can cause diarrhea, nausea, and abdominal cramps. High intake may be a concern with hyperoxaluria, kidney disease or hereditary hemochromatosis, and high-dose use during chemotherapy or radiation should be discussed with the treating clinician.
- high-dose use with hyperoxaluria or significant kidney disease without clinical guidance
- high-dose use with hereditary hemochromatosis without clinical guidance
- diarrhea at high doses
- nausea at high doses
- abdominal cramps at high doses
- chemotherapy or radiation therapy
- niacin plus simvastatin antioxidant regimens