What it’s for
- Marketed for relaxation and sleep
A plant flavonoid sold as an isolated supplement and also present in foods and chamomile.
Purpose, evidence and practical considerations.
The cited human study concerns absorption, not a sleep treatment. Poor absorption and laboratory mechanisms do not establish that isolated apigenin improves insomnia, anxiety or longevity.
Confidence: unsupported
Human safety data for isolated high-dose apigenin are sparse. It may interact with sedatives, anticoagulants and medicines handled by CYP enzymes; pregnancy, breastfeeding and long-term use have not been adequately studied.
Apigenin binds several molecular targets in laboratory studies, including benzodiazepine-related GABA-A sites and CD38. Human absorption of isolated apigenin is poor, and no human outcome trial establishes that a 50 mg capsule improves sleep.
Regulatory status: dietary supplement ingredient; not an FDA-approved sleep or anxiety treatment
The evidence on this page does not automatically apply to:
How people use it, with their schedules, context and original sources.
50 mg · 30–60 min before bed
30 min before sleep
Amount and timing patterns reported in public protocols; these are observations, not instructions. Private and hidden usage is excluded.
These share a protocol with this intervention. This does not establish that they work together or are suitable alternatives.