What it is
Regulatory status: prescription medication
Mechanism evidence: human
At a glance
What it is, why people use it, the evidence, and what to know before trying it.
Why people use it
- Lower serum urate in adults with gout when allopurinol is inadequate, not tolerated, or inadvisable
Evidence at a glance
Febuxostat effectively lowers urate but is a prescription gout medicine with material cardiovascular and interaction considerations. Its place in therapy requires clinician judgment rather than protocol copying.
Confidence: strong
Clinical safety
Contraindications, interactions and clinical cautions from reviewed sources.
US labeling carries a boxed warning about cardiovascular death. Liver effects and gout flares require monitoring, and the drug is contraindicated with azathioprine or mercaptopurine.
- concurrent azathioprine or mercaptopurine
- azathioprine
- mercaptopurine
- theophylline
Forms and variants
This review does not automatically apply to:
- allopurinol
- uricosuric medicines
- acute gout-flare treatments
Seen in protocols
Public protocols that include Febuxostat. Open one to see the full context and source.