What it is
Regulatory status: dietary supplement
At a glance
What it is, why people use it, the evidence, and what to know before trying it.
Why people use it
- Lowers systemic inflammation (IL-6, IL-8, hs-CRP, SASP).
- Clears senescent cells / lowers senescence markers in blood.
- Improves cognition / memory / delays cognitive decline.
- Adequate oral bioavailability at 100 mg unformulated to reach the above targets.
- Safe as a daily supplement.
- Kills senescent cells in humans (hit-and-run).
- Improves frailty / gait / physical function in older adults (the Mayo AFFIRM claim).
- Treats knee osteoarthritis (pain, function, cartilage).
- Improves COVID-19 severity / complications.
- Improves vascular endothelial function.
Evidence at a glance
**Track A — 100 mg daily. Confidence: weak** for a short-term IL-8 reduction in people on colorectal-cancer chemotherapy (one n = 37 RCT; only IL-8 beat placebo). **Unsupported** as a senolytic, as a cognitive drug, as a general anti-inflammatory in healthy or multimorbid older adults, and as a bioavailable way to reach the micromolar concentrations used in explants and cell screens. The Hambright n = 10 self-report is a signal, not a trial; the trial designed to test 100 mg daily in healthy adults (NCT07195318) has not reported. Unformulated oral fisetin at even 1,000 mg barely appears in plasma.
Seen in protocols
Public protocols that include Fisetin — evidence review (100 mg daily vs senolytic high-dose). Open one to see the full context and source.