DDavid SinclairUnclaimedSupplement Protocol · 13 interventions

Longevity Supplement Stack

Supplement Protocol · 13 interventions

Sinclair's NAD+/sirtuin-focused supplement and prescription protocol. Core thesis: activate survival pathways through NMN, resveratrol, and fasting mimetics.

Supplement

01Intervention stacks13 interventions

Section 01 · Supplements10 interventions

01
Nicotinamide Mononucleotide (NMN)
Dose & timing
1g Daily · Morning, mixed in yogurt
NAD+ precursor — fuels sirtuins for DNA/epigenome repair
^§Lifespan Podcast Ep.3
02
Resveratrol
Dose & timing
1g Daily · Morning, with fat (yogurt) for absorption
Sirtuin activator — "accelerator pedal" for sirtuin genes
^§Lifespan (2019)
03
TMG (Trimethylglycine)
Dose & timing
500-1,000 mg Daily
Methyl donor — counteracts methylation depletion from NMN
^§NOVOS analysis
04
Spermidine
Dose & timing
1-2 mg Daily · Morning
Autophagy activator — cellular renewal
^§Lifespan Podcast Ep.3
05
Quercetin
Dose & timing
500 mg Daily · Morning
Senolytic — clears senescent cells, anti-inflammatory
^§Lifespan Podcast Ep.3
06
Fisetin
Dose & timing
500 mg Daily · Morning
Senolytic — clears senescent cells
^§Lifespan Podcast Ep.3
07
Vitamin D3
Dose & timing
4,000-5,000 IU Daily
Immune, bone, mood support
^§Lifespan (2019)
08
Vitamin K2
Dose & timing
180-360 mcg Daily
Calcium metabolism, arterial health
^§Lifespan (2019)
09
Taurine
Dose & timing
2g Daily
Mitochondrial and cardiovascular function
^§omre.co (2025)
10
Low-dose Aspirin
Dose & timing
83 mg Daily
Anti-inflammatory, potential cancer risk reduction
^§Lifespan (2019)

Section 02 · Medications3 interventions

11
Metformin
Dose & timing
800-1,000 mg Daily · Evening
Fasting mimetic — AMPK activation, metabolic support
^§Lifespan (2019)
12
Statin (high dose)
Dose & timing
Dose unspecified Daily
Genetically high cholesterol — on statins since age 29
^§Joe Rogan #1349
13
Rapamycin
Dose & timing
Dose unconfirmed Daily · Weekly
mTOR inhibitor — caloric restriction mimetic (recent addition)
^§omre.co (2025)

Filed under

longevityNAD+sirtuinsanti-aging

02Citations4 links

01Lifespan Podcast Ep.3Nicotinamide Mononucleotide (NMN)
02NOVOS analysisTMG (Trimethylglycine)
03omre.co (2025)Taurine
04Joe Rogan #1349Statin (high dose)

03Edit history1 editions

v1Current versionFebruary 18, 2026 · Initial edition

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