Longevity Supplement Stack
Sinclair's NAD+/sirtuin-focused supplement and prescription protocol. Core thesis: activate survival pathways through NMN, resveratrol, and fasting mimetics.
Interventions
Supplements
- Nicotinamide Mononucleotide (NMN)
1g · Daily · Morning, mixed in yogurt
NAD+ precursor — fuels sirtuins for DNA/epigenome repair
Details & sources
- Resveratrol
1g · Daily · Morning, with fat (yogurt) for absorption
Sirtuin activator — "accelerator pedal" for sirtuin genes
Details & sources
- TMG (Trimethylglycine)
500-1,000 mg · Daily
Methyl donor — counteracts methylation depletion from NMN
Details & sources
- Quercetin
500 mg · Daily · Morning
Senolytic — clears senescent cells, anti-inflammatory
Details & sources
Medications
- Metformin
800-1,000 mg · Daily · Evening
Fasting mimetic — AMPK activation, metabolic support
Details & sources
- Statin (high dose)
Dose unspecified · Daily
Genetically high cholesterol — on statins since age 29
Details & sources
- Rapamycin
Dose unconfirmed · Daily · Weekly
mTOR inhibitor — caloric restriction mimetic (recent addition)
Details & sources
Sources
Original accounts behind this protocol. Numbers match the references in each intervention.
- 01Lifespan Podcast Ep.3 ↗Nicotinamide Mononucleotide (NMN) · Resveratrol · Spermidine · Quercetin · Fisetin · Vitamin D3 · Vitamin K2 · Low-dose Aspirin · Metformin
- 02NOVOS analysis ↗TMG (Trimethylglycine)
- 03omre.co (2025) ↗Taurine · Rapamycin
- 04Joe Rogan #1349 ↗Statin (high dose)
Edit history
- v1Current versionFebruary 18, 2026