Phosphatidylserine: What It Is, Uses, Evidence & Safety

At a glance

Purpose, evidence and practical considerations.

What it’s for

Studied for selected cognitive symptoms

What the evidence says

Studies vary in population and formulation, including mixtures with other compounds. They do not establish phosphatidylserine alone as an effective jet-lag treatment.

Confidence: weak

Safety & interactions

Short studies generally report mild gastrointestinal or sleep effects, but long-term data and interaction data are limited. Soy-derived products may matter for allergies.

How it works & important distinctions

Phosphatidylserine is a membrane phospholipid involved in cell signaling. Oral supplements may affect stress or cognitive measures, but small heterogeneous studies do not establish a reliable clinical effect.

Regulatory status: dietary supplement; not FDA-approved to treat jet lag, dementia or stress disorders

Different forms

The evidence on this page does not automatically apply to:

phosphatidylcholine
serine
multi-ingredient stress or sleep blends

In these protocols

How people use it, with their schedules, context and original sources.

Peter AttiaDaily supplements

Date of record:: 23 Oct 2023

~400 mg · occasional, when travelling · on long flights
jet lag / time-zone changes

Details & sources

Occasional, not daily. The Drive

Common dose and timing

Amount and timing patterns reported in public protocols; these are observations, not instructions. Private and hidden usage is excluded.

Typical amount

~400 mg1 public entry

Frequency

occasional, when travelling1 public entry

Timing

on long flights1 public entry

Popular brands

Brand variants reported in public protocols. Private entries are excluded, and inclusion is not an endorsement.

Jarrow1 public entry

Other items in these protocols

These share a protocol with this intervention. This does not establish that they work together or are suitable alternatives.