What it is
Regulatory status: the former FDA-approved Geref product was discontinued; current compounded sermorelin is not an FDA-approved finished drug
Mechanism evidence: human
At a glance
What it is, why people use it, the evidence, and what to know before trying it.
Why people use it
- Diagnostic or historical treatment use in growth-hormone deficiency
- Recovery
- Sleep or body-composition support
Evidence at a glance
Sermorelin has a real growth-hormone-releasing mechanism but no established role as a general sleep, recovery or longevity treatment. Current compounded use should not be represented as equivalent to an approved anti-aging therapy.
Confidence: moderate
Clinical safety
Contraindications, interactions and clinical cautions from reviewed sources.
Sermorelin can cause injection reactions, flushing, headache, dizziness and hormone-related adverse effects. Compounded products add sterility, identity and dosing uncertainty; use requires licensed clinical oversight.
- Active malignancy without specialist guidance
- Use of unverified injectable products
- Injection-site reaction
- Headache
- Flushing
- Dizziness
- Glucocorticoids and other medicines affecting growth-hormone testing or response
Forms and variants
This review does not automatically apply to:
- tesamorelin
- growth hormone or somatropin
- unverified peptide blends