David Sinclair
3 interventions
Daily supplements
Lifespan Ep. 4: ~1 g resveratrol with fat, 1 g NMN, metformin 800 mg at night (skip before exercise); Altucher 2026: back on metformin SR 1 g/day
1metformin
2NMN
3resveratrol
David Sinclair
Unclaimed
Known for Professor of Genetics at Harvard Medical School, author of NYT bestseller "Lifespan," co-director of Paul F. Glenn Center for Biology of Aging.
Harvard genetics professor researching why we age — and why we don't have to. Pioneer of the Information Theory of Aging and NAD+/sirtuin science.
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This is an unclaimed profile. The protocols below were compiled from public interviews, articles, and podcasts — they were not added by David Sinclair, and this page is not affiliated with or endorsed by them.
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4 protocolsDavid Sinclair
13 interventions
Longevity Supplement Stack
Sinclair's NAD+/sirtuin-focused supplement and prescription protocol. Core thesis: activate survival pathways through NMN, resveratrol, and fasting mimetics.
1Nicotinamide Mononucleotide (NMN)1g · Morning, mixed in yogurt
2Resveratrol1g · Morning, with fat (yogurt) for absorption
3TMG (Trimethylglycine)500-1,000 mg · Daily
+10 more
David Sinclair
5 interventions
Exercise & Hormetic Stress
Sinclair's exercise and wellness practices built on hormesis: "What doesn't kill you makes you live longer."
1Running (high intensity)Varies · 1-2x/week
2Weight TrainingVaries · 2-3x/week
3BoxingVaries · Regular
+2 more
David Sinclair
5 interventions
Diet & Intermittent Fasting
Sinclair's plant-forward diet with 16:8 intermittent fasting. Philosophy: mild biological stress activates longevity pathways.
1Time-Restricted EatingSkip breakfast, often lunch too · Daily
2Plant-forward dietHeavy on vegetables, mushrooms, pulses, whole grains · Daily
3Limited red meatFish and occasional chicken; avoids red meat · Ongoing
+2 more