Daily supplements

Sinclair’s own January 2022 podcast gives older exact amounts for morning NMN and resveratrol and corrects an on-air spermidine unit error. A July 2026 interview separately records current-status changes: intermittent berberine while pausing metformin, a nattokinase trial, and no longer taking taurine regularly. These are personal experiments, not longevity recommendations.

Reported practice

Date of record:: 3 Jul 2026

Interventions

Supplements

Resveratrol
~1 g · Daily · morning, with yogurt or olive oil
Provisional
sirtuin activator; taken with fat or it 'will mostly pass straight through you'
Details & sources
Dose and timing from Lifespan Ep. 4 (Jan 2022; taken since 2004); personal grams not restated in the Jul 2026 interview, where resveratrol is named only in his father's combination
Sources1
NMN
1 g · Daily · morning
NAD precursor; 'the one that I take is NMN'
Details & sources
1 g figure is from Lifespan Ep. 4 (Jan 2022); Jul 2026: 'taking NMN... probably for 15 years', no grams. He co-founded Metro International Biotech, an NMN drug developer
Sources1 2
Spermidine
capsules; 1–2 mg active per official correction
Provisional
Details & sources
Said '1 gram of Spermidine' on Lifespan Ep. 4 (Jan 2022); the Sinclair-owned show notes correct this to 1–2 mg active ingredient. Not restated since
Sources1
Berberine
intermittent, while pausing metformin
Provisional
substitute when metformin upsets his stomach
Details & sources
Jul 2026: 'I switch for a while' to berberine when acid sensitivity makes him pause metformin; dose not stated; he was going back on metformin at that interview
Sources2
Nattokinase
Details & sources
Jul 2026: 'I'm trying that one'; experimental, dose not stated
Sources2
Taurine
Stopped · Date not stated
Details & sources
Tried it; Jul 2026: 'I'm not currently taking taurine regularly'
Sources2

Sources

Original accounts behind this protocol. Numbers match the references in each intervention.

01NMN, NR, Resveratrol, Metformin and Other Molecules for Longevity Resveratrol · NMN · Spermidine
02Dr. David Sinclair — The First Human Trial of an Age-Reversal Therapy NMN · Berberine · Nattokinase · Taurine

Resveratrol and NMN grams are Jan 2022 statements (Lifespan Ep. 4, protocol segment ~1:02:43) reached via a Podcast Notes recap; the Sinclair-owned show-notes page prints only the spermidine correction. The Jul 2026 Altucher interview confirms NMN, berberine, taurine and nattokinase status but restates no grams