Prescriptions
Sinclair described an older metformin routine on his January 2022 podcast, then said in July 2026 that stomach sensitivity had led to intermittent pauses and that he was returning to slow-release metformin at 1 g daily. This is a dated account of a prescription used under medical supervision, not advice to use metformin for longevity.
Reported protocol · For reference, not advice
Interventions
Medication
- Metformin
1 g/day · daily, with intermittent pauses
AMPK activation; to 'simulate a fast'
Details & sources
Sources
Original accounts behind this protocol. Numbers match the references in each intervention.
- 01NMN, NR, Resveratrol, Metformin and Other Molecules for Longevity ↗Source for this protocol
- 02Dr. David Sinclair — The First Human Trial of an Age-Reversal Therapy ↗Source for this protocol
The 1 g slow-release figure is first-person on the Altucher show (3 Jul 2026, not Sinclair-owned); the 800 mg night regimen is from Lifespan Ep. 4 (Jan 2022) via a Podcast Notes recap. No Sinclair-owned 2025–26 page confirms either