Fadogia agrestis

Regulatory status: dietary supplement

Mechanism evidence: animal

• **Serum testosterone** (the commercial claim).
• **Libido / sexual desire** (mount and intromission behaviour in rats; traditional aphrodisiac use).
• **Erectile function** (traditional ED use; 2022 paroxetine-ED rat model).
• **Male fertility / sperm** (sometimes implied by the T claim; the 28-day rat papers go the other way).
• **Athletic performance / lean mass** (label claim only; no study was found that measured either).
• **Antipyretic / antimalarial** (traditional use; one *in vitro* *P. falciparum* screen).

*Fadogia agrestis* is an unstandardised West African shrub extract whose entire testosterone-and-libido reputation rests on **one laboratory’s rat papers from 2005–2009**, plus a 2022 paroxetine-ED follow-up from the same group. In those rats, 5 days of aqueous stem extract raised serum T about **2× / 3× / 6×** at 18 / 50 / 100 mg/kg and increased copulatory behaviour. **The same doses, given for 28 days, damaged testicular biochemistry, cut sperm indices at 50 and 100 mg/kg, and produced irreversible seminiferous-tubule destruction at those two doses**, with liver- and kidney-membrane leakage and higher MDA at all three doses. That is not “mixed human evidence.” That is **animal benefit and animal harm on the same dose ladder, and no human test of either**.

Confidence: unsupported