What it is
Regulatory status: FDA-cleared chambers and medical oxygen are used for specific conditions; broad anti-aging or longevity use is not an established UHMS indication.
Mechanism evidence: human
At a glance
What it is, why people use it, the evidence, and what to know before trying it.
Why people use it
- Treatment of selected recognized hyperbaric indications
- Experimental recovery and aging-related biomarker effects
Evidence at a glance
HBOT is evidence-based for a defined set of medical indications. Bryan Johnson's 60-session longevity experiment is outside those established indications, and biomarker findings do not show longer life or better clinical outcomes.
Confidence: strong
Practice safety
Situations where this practice may need modification or professional guidance.
Common risks include ear or sinus barotrauma, temporary vision changes and oxygen-related symptoms. Rare but serious risks include oxygen seizures, lung injury, fire and chamber accidents. Untreated pneumothorax is a contraindication; treatment belongs in an accredited medical program with trained staff.
Forms and variants
This review does not automatically apply to:
- mild hyperbaric air chambers
- normobaric supplemental oxygen
- oxygen bars
Seen in protocols
Public protocols that include Hyperbaric oxygen therapy. Open one to see the full context and source.