NMN (β-nicotinamide mononucleotide): What It Is, Uses, Evidence & Safety

At a glance

Purpose, evidence and practical considerations.

What it’s for

Studied for NAD metabolism

What the evidence says

Short oral trials show changes in NAD-related markers, with selected metabolic findings in specific populations. They have not established longer life or equivalent benefits from sublingual products.

Confidence: moderate

Safety & interactions

Short trials generally report tolerability over weeks to a few months, but long-term safety is not established. Product identity and purity are important because consumer NMN is not equivalent to pharmaceutical trial material. Pregnancy, cancer treatment, liver or kidney disease and medication use warrant clinician review.

How it works & important distinctions

Beta-nicotinamide mononucleotide is an NAD+ precursor. Oral NMN raises circulating NAD-related metabolites in short human trials, but a higher blood NAD+ measurement is a biochemical surrogate and does not establish improved organ function or slower aging.

Regulatory status: dietary supplement (vitamin B3-related NAD+ precursor). Not a prescription drug in any major market as of August 2026. A pharmaceutical-grade microcrystalline polymorph (MIB-626, Metro International Biotech) is in company-sponsored drug trials

In these protocols

How people use it, with their schedules, context and original sources.

Andrew HubermanSupplements and personal experiments

Date of record:: 6 Mar 2026

morning
Perceived energy, rather than longevity.

Details & sources

He describes stopping and restarting the powder to compare his own experience, and reports faster hair growth. He says he does not know whether others experience the same effect.
Source 3 · 1 Dec 2025

No amount is given. Oral NMN studies do not establish effects for this sublingual product or his reported hair-growth experience.

Bryan JohnsonDaily supplements

Common dose and timing

Amount and timing patterns reported in public protocols; these are observations, not instructions. Private and hidden usage is excluded.

Typical amount

500 mg1 public entry · 50%
1 g1 public entry · 50%

Frequency

Daily2 public entries · 100%
Full reported context
daily

Timing

morning3 public entries · 100%

Popular brands

Brand variants reported in public protocols. Private entries are excluded, and inclusion is not an endorsement.

Renue by Science1 public entry · 50%
Blueprint1 public entry · 50%

Other items in these protocols

These share a protocol with this intervention. This does not establish that they work together or are suitable alternatives.